abstract：:Contemporary psychiatry faces major challenges. Its syndrome-based disease classification is not based on mechanisms and does not guide treatment, which largely depends on trial and error. The development of therapies is hindered by ignorance of potential beneficiary patient subgroups. Neuroscientific and genetics res...

journal_title：The lancet. Psychiatry

authors： Stephan KE,Bach DR,Fletcher PC,Flint J,Frank MJ,Friston KJ,Heinz A,Huys QJM,Owen MJ,Binder EB,Dayan P,Johnstone EC,Meyer-Lindenberg A,Montague PR,Schnyder U,Wang XJ,Breakspear M

更新日期：2016-01-01 00:00:00

abstract：BACKGROUND:Depressive symptoms are a major cause of disability in bipolar disorder and there are few safe and effective treatments. The combination of lamotrigine plus quetiapine potentially offers improved outcomes for people with bipolar depression. We aimed to determine if combination therapy with quetiapine plus la...

journal_title：The lancet. Psychiatry

authors： Geddes JR,Gardiner A,Rendell J,Voysey M,Tunbridge E,Hinds C,Yu LM,Hainsworth J,Attenburrow MJ,Simon J,Goodwin GM,Harrison PJ,CEQUEL Investigators and Collaborators.

更新日期：2016-01-01 00:00:00

abstract：BACKGROUND:The PACE trial found that, when added to specialist medical care (SMC), cognitive behavioural therapy (CBT), or graded exercise therapy (GET) were superior to adaptive pacing therapy (APT) or SMC alone in improving fatigue and physical functioning in people with chronic fatigue syndrome 1 year after randomis...

journal_title：The lancet. Psychiatry

authors： Sharpe M,Goldsmith KA,Johnson AL,Chalder T,Walker J,White PD

更新日期：2015-12-01 00:00:00

abstract：:Autism spectrum conditions comprise a set of early-onset neurodevelopmental syndromes with a prevalence of 1% across all ages. First diagnosis in adulthood has finally become recognised as an important clinical issue due to the increasing awareness of autism, broadening of diagnostic criteria, and the introduction of ...

journal_title：The lancet. Psychiatry

authors： Lai MC,Baron-Cohen S

更新日期：2015-11-01 00:00:00

abstract：BACKGROUND:Autism spectrum disorder (ASD) phenomenology is reported to be more common in individuals with some genetic syndromes than in the general population; however, no meta-analysis has provided prevalence data within and between syndromes. In this systematic review and meta-analysis, we aimed to synthesise data f...

journal_title：The lancet. Psychiatry

authors： Richards C,Jones C,Groves L,Moss J,Oliver C

更新日期：2015-10-01 00:00:00

abstract：BACKGROUND:Many older adults with major depression, particularly veterans, do not have access to evidence-based psychotherapy. Telemedicine could increase access to best-practice care for older adults facing barriers of mobility, stigma, and geographical isolation. We aimed to establish non-inferiority of behavioural a...

journal_title：The lancet. Psychiatry

authors： Egede LE,Acierno R,Knapp RG,Lejuez C,Hernandez-Tejada M,Payne EH,Frueh BC

更新日期：2015-08-01 00:00:00

abstract：BACKGROUND:Early social deprivation can negatively affect domains of functioning. We examined psychopathology at age 12 years in a cohort of Romanian children who had been abandoned at birth and placed into institutional care, then assigned either to be placed in foster care or to care as usual. METHODS:We used follow...

journal_title：The lancet. Psychiatry

authors： Humphreys KL,Gleason MM,Drury SS,Miron D,Nelson CA 3rd,Fox NA,Zeanah CH

更新日期：2015-07-01 00:00:00

abstract：:The aim of this Review is to identify effective interventions and treatment guidelines to manage common types of psychiatric emergencies in non-specialist settings in low-income and middle-income countries. Mental health specialist services in low-income and middle-income countries are scarce. We did a systematic revi...

journal_title：The lancet. Psychiatry

authors： Nadkarni A,Hanlon C,Bhatia U,Fuhr D,Ragoni C,de Azevedo Perocco SL,Fortes S,Shidhaye R,Kinyanda E,Rangaswamy T,Patel V

更新日期：2015-06-01 00:00:00

abstract：BACKGROUND:With a lifetime risk for major depressive disorder of up to 50%, depression is a common comorbidity in multiple sclerosis but remains widely underdiagnosed and untreated. We investigated the potential of a fully automated, internet-based, cognitive behavioural therapy programme, Deprexis, to reduce depressiv...

journal_title：The lancet. Psychiatry

authors： Fischer A,Schröder J,Vettorazzi E,Wolf OT,Pöttgen J,Lau S,Heesen C,Moritz S,Gold SM

更新日期：2015-03-01 00:00:00

abstract：BACKGROUND:Cognitive behaviour therapy (CBT) added to specialist medical care (SMC), or graded exercise therapy (GET) added to SMC, are more effective in reducing fatigue and improving physical function than both adaptive pacing therapy (APT) plus SMC and SMC alone for chronic fatigue syndrome. We investigate putative ...

journal_title：The lancet. Psychiatry

authors： Chalder T,Goldsmith KA,White PD,Sharpe M,Pickles AR

更新日期：2015-02-01 00:00:00

abstract：BACKGROUND:The first episode of psychosis is a crucial period when early intervention can alter the trajectory of the young person's ongoing mental health and general functioning. After an investigation into completed suicides in the Early Psychosis Prevention and Intervention Centre (EPPIC) programme, the intensive ca...

journal_title：The lancet. Psychiatry

authors： Brewer WJ,Lambert TJ,Witt K,Dileo J,Duff C,Crlenjak C,McGorry PD,Murphy BP

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND:Adults with intellectual disabilities have substantial health inequalities and poor access to health care. We assessed whether practice nurse-delivered health checks could improve the health of adults with intellectual disabilities compared with standard care. METHODS:In this cluster-design, single-blind, r...

journal_title：The lancet. Psychiatry

authors： Cooper SA,Morrison J,Allan LM,McConnachie A,Greenlaw N,Melville CA,Baltzer MC,McArthur LA,Lammie C,Martin G,Grieve EA,Fenwick E

更新日期：2014-12-01 00:00:00

abstract：BACKGROUND:In high-income countries, maternal postnatal depression is associated with adverse outcomes in the child. However, few studies have investigated this relation in countries of low and middle income. Furthermore, to our knowledge, no studies have followed up cohorts into later childhood. We aimed to investigat...

journal_title：The lancet. Psychiatry

authors： Verkuijl NE,Richter L,Norris SA,Stein A,Avan B,Ramchandani PG

更新日期：2014-11-01 00:00:00

abstract：BACKGROUND:Social anxiety disorder-a chronic and naturally unremitting disease that causes substantial impairment-can be treated with pharmacological, psychological, and self-help interventions. We aimed to compare these interventions and to identify which are most effective for the acute treatment of social anxiety di...

journal_title：The lancet. Psychiatry

authors： Mayo-Wilson E,Dias S,Mavranezouli I,Kew K,Clark DM,Ades AE,Pilling S

更新日期：2014-10-01 00:00:00

abstract：BACKGROUND:The definition of post-traumatic stress disorder (PTSD) underwent substantial changes in the 2013 edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM-5). How this will affect estimates of prevalence, whether clinical utility has been improved, and how many individuals who meet symptom c...

journal_title：The lancet. Psychiatry

authors： Hoge CW,Riviere LA,Wilk JE,Herrell RK,Weathers FW

更新日期：2014-09-01 00:00:00

abstract：BACKGROUND:Anxiety in children is common, impairs everyday functioning, and increases the risk of severe mental health disorders in adulthood. We investigated the effect of a classroom-based cognitive behaviour therapy prevention programme (FRIENDS) on anxiety symptoms in children. METHODS:Preventing Anxiety in Childr...

journal_title：The lancet. Psychiatry

authors： Stallard P,Skryabina E,Taylor G,Phillips R,Daniels H,Anderson R,Simpson N

更新日期：2014-08-01 00:00:00

abstract：BACKGROUND:Acting on command hallucinations in psychosis can have serious consequences for the individual and for other people and is a major cause of clinical and public concern. No evidence-based treatments are available to reduce this risk behaviour. We therefore tested our new cognitive therapy to challenge the per...

journal_title：The lancet. Psychiatry

authors： Birchwood M,Michail M,Meaden A,Tarrier N,Lewis S,Wykes T,Davies L,Dunn G,Peters E

更新日期：2014-06-01 00:00:00